Proteome-wide Analysis and CXCL4 as a …Original Article. Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis. Lenny van Bon, M.D., Alsya J. Affandi, M.Sc., Jasper Broen, M.D., Ph.D., Romy ... http://www.nejm.org/doi/full/10.1056/NEJMoa1114576